HIV-Specific Cytolytic CD4 T Cell Responses During Acute HIV Infection Predict Disease Outcome-Reference-Cited by-同舟云学术

HIV-Specific Cytolytic CD4 T Cell Responses During Acute HIV Infection Predict Disease Outcome

Published:2012-02-29 Issue:123 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Soghoian Damien Z.¹,Jessen Heiko²,Flanders Michael¹,Sierra-Davidson Kailan¹,Cutler Sam¹,Pertel Thomas¹,Ranasinghe Srinika¹,Lindqvist Madelene¹,Davis Isaiah¹,Lane Kimberly¹,Rychert Jenna³,Rosenberg Eric S.³,Piechocka-Trocha Alicja¹,Brass Abraham L.¹,Brenchley Jason M.⁴,Walker Bruce D.¹⁵,Streeck Hendrik¹

Affiliation:

1. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard Medical School, Charlestown, MA 02129, USA.

2. Practice Jessen-Jessen-Stein, 10777 Berlin, Germany.

3. Infectious Disease Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

4. Laboratory of Molecular Microbiology, National Institutes of Health, Bethesda, MD 20892, USA.

5. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

HIV-specific CD4 T cell responses during acute infection show robust cytolytic activity and correlate with a lower viral set point and better clinical outcome.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference48 articles.

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5. Natural History of Human Immunodeficiency Virus Type 1 Viremia after Seroconversion and Proximal to AIDS in a Large Cohort of Homosexual Men

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