Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17–Driven Inflammatory Bone Loss

Author:

Moutsopoulos Niki M.1,Konkel Joanne2,Sarmadi Mojgan1,Eskan Mehmet A.3,Wild Teresa1,Dutzan Nicolas1,Abusleme Loreto1,Zenobia Camille4,Hosur Kavita B.4,Abe Toshiharu4,Uzel Gulbu5,Chen WanJun2,Chavakis Triantafyllos6,Holland Steven M.5,Hajishengallis George4

Affiliation:

1. National Institute of Dental and Craniofacial Research, Oral Immunity and Infection Unit, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.

2. National Institute of Dental and Craniofacial Research, Mucosal Immunology Section, Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD 20892, USA.

3. Oral Health and Systemic Disease Research Group, University of Louisville School of Dentistry, Louisville, KY 40202, USA.

4. Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA.

5. National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

6. Department of Medicine, Department of Clinical Pathobiochemistry, and Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.

Abstract

Inflammatory bone loss from periodontal infections in leukocyte adhesion deficiency disease can be reversed by treatment with antibodies to IL-17 or IL-23.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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