Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4

Author:

Ren Yin1,Cheung Hiu Wing23,von Maltzhan Geoffrey1,Agrawal Amit1,Cowley Glenn S.3,Weir Barbara A.3,Boehm Jesse S.3,Tamayo Pablo3,Karst Alison M.2,Liu Joyce F.2,Hirsch Michelle S.3,Mesirov Jill P.34,Drapkin Ronny25,Root David E.3,Lo Justin1,Fogal Valentina67,Ruoslahti Erkki67,Hahn William C.2389,Bhatia Sangeeta N.134810

Affiliation:

1. Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

3. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

4. Electrical Engineering and Computer Science and DF2avid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

6. Center for Nanomedicine, Sanford-Burnham Medical Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.

7. Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

8. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

9. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

10. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

Tumor-penetrating siRNA nanocomplexes credential ID4 as a therapeutic oncogene target in human ovarian cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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