Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome-Reference-Cited by-同舟云学术

Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome

Published:2012-04-25 Issue:131 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lu Zhongju¹,Wu Chia-Yen C.¹,Jiang Ya-Ping¹,Ballou Lisa M.¹,Clausen Chris¹,Cohen Ira S.¹,Lin Richard Z.¹²

Affiliation:

1. Department of Physiology and Biophysics and the Institute for Molecular Cardiology, Stony Brook University, Stony Brook, NY 11794, USA.

2. Northport Veterans Affairs Medical Center, Northport, NY 11768, USA.

Abstract

The dangerous heart arrhythmias that are triggered as a side effect of some drugs are caused by many ion channels, prompting a rethinking of how we screen for these adverse events.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference41 articles.

1. The genetic basis of long QT and short QT syndromes: A mutation update

2. Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

3. Drug-Induced Prolongation of the QT Interval

4. The Non-Clinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use Geneva 2005).

5. hERG Potassium Channels and the Structural Basis of Drug-Induced Arrhythmias

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