TCR-Ligand k off Rate Correlates with the Protective Capacity of Antigen-Specific CD8 + T Cells for Adoptive Transfer-Reference-Cited by-同舟云学术

TCR-Ligand k off Rate Correlates with the Protective Capacity of Antigen-Specific CD8 + T Cells for Adoptive Transfer

Published:2013-07-03 Issue:192 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Nauerth Magdalena¹,Weißbrich Bianca¹,Knall Robert¹,Franz Tobias¹,Dössinger Georg¹,Bet Jeannette¹²,Paszkiewicz Paulina J.¹²,Pfeifer Lukas¹,Bunse Mario³⁴,Uckert Wolfgang³⁴,Holtappels Rafaela⁵,Gillert-Marien Dorothea⁵,Neuenhahn Michael¹⁶⁷,Krackhardt Angela⁶⁸,Reddehase Matthias J.⁵⁹,Riddell Stanley R.²¹⁰,Busch Dirk H.¹²⁶⁷

Affiliation:

1. Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.

2. Focus Group “Clinical Cell Processing and Purification,” Institute for Advanced Study, Technische Universität München, 81675 Munich, Germany.

3. Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.

4. Humboldt-Universität Berlin, 10099 Berlin, Germany.

5. Institute for Virology and Research Center for Immunology (FZI), University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.

6. Clinical Cooperation Groups “Antigen-specific Immunotherapy” and “Immune Monitoring,” Helmholtz Center Munich (85764 Neuherberg) and Technische Universität München, 81675 Munich, Germany.

7. DZIF–National Centre for Infection Research, 81675 Munich, Germany.

8. Medical Department III, Hematology and Oncology, Technische Universität München, 81675 Munich, Germany.

9. Helmholtz Virtual Institute on Viral Strategies of Immune Evasion (VISTRIE), Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

10. Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

A Strep tamer-based k off rate assay identifies T cells with high protective capacity for the adoptive transfer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference30 articles.

1. Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation

2. Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

3. Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

4. Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma

5. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

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