5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids

Author:

Sapieha Przemyslaw12,Stahl Andreas13,Chen Jing1,Seaward Molly R.1,Willett Keirnan L.1,Krah Nathan M.1,Dennison Roberta J.1,Connor Kip M.1,Aderman Christopher M.1,Liclican Elvira4,Carughi Arianna56,Perelman Dalia56,Kanaoka Yoshihide7,SanGiovanni John Paul8,Gronert Karsten4,Smith Lois E. H.1

Affiliation:

1. Department of Ophthalmology, Harvard Medical School, Children’s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.

2. Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada H1T 2M4.

3. University Eye Hospital Freiburg, Killianstrasse 5, Freiburg 79106, Germany.

4. Vision Science Program, School of Optometry, University of California, Berkeley, CA 94720, USA.

5. Health Research and Studies Center, Los Altos, CA 94022, USA.

6. Palo Alto Medical Foundation, Palo Alto, CA 94301, USA.

7. Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA.

8. Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, MD 20892, USA

Abstract

In mice, ω-3 fatty acids in the diet are converted by 5-lipoxygenase to a metabolite that inhibits destructive vessel growth similar to diabetic retinopathy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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