Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia

Author:

Soehnlein Oliver123,Wantha Sarawuth3,Simsekyilmaz Sakine34,Döring Yvonne13,Megens Remco T. A.13,Mause Sebastian F.35,Drechsler Maik136,Smeets Ralf7,Weinandy Stefan48,Schreiber Fabian9,Gries Thomas9,Jockenhoevel Stefan8,Möller Martin4,Vijayan Santosh3,van Zandvoort Marc A. M. J.23,Agerberth Birgitta10,Pham Christine T.11,Gallo Richard L.12,Hackeng Tilman M.2,Liehn Elisa A.34,Zernecke Alma6,Klee Doris4,Weber Christian123

Affiliation:

1. Institute for Cardiovascular Prevention, Ludwig-Maximilians University München, Munich 80336, Germany.

2. Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht 6200, Netherlands.

3. Institute for Molecular Cardiovascular Research, Interdisciplinary Center for Clinical Research, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Aachen 52074, Germany.

4. Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Aachen 52074, Germany.

5. Medical Clinic I, RWTH Aachen University, Aachen 52074, Germany.

6. Rudolf Virchow Center/DFG Research Center for Experimental Biomedicine, Julius-Maximilians-University Würzburg, Würzburg 97080, Germany.

7. Department of Oral and Maxillofacial Surgery, RWTH Aachen University, Aachen 52074, Germany.

8. Department of Applied Medical Engineering, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen 52074, Germany.

9. Institute for Textile Technology, RWTH Aachen University, Aachen 52074, Germany.

10. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden.

11. Department of Surgery, Washington University, St. Louis, WA 63110, USA.

12. Department of Medicine, University of California, San Diego, La Jolla, CA 92126, USA.

Abstract

Cathelicidin-coated stents limit neointima formation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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