Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR-Reference-Cited by-同舟云学术

Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

Published:2013-11-20 Issue:212 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rottiers Veerle¹²,Obad Susanna³,Petri Andreas³⁴,McGarrah Robert⁵⁶⁷,Lindholm Marie W.³,Black Joshua C.¹⁸,Sinha Sumita⁵⁶,Goody Robin J.⁹,Lawrence Matthew S.⁹,deLemos Andrew S.¹⁰,Hansen Henrik F.³,Whittaker Steve⁹,Henry Steve⁹,Brookes Rohn⁹,Najafi-Shoushtari Seyed Hani¹²¹¹,Chung Raymond T.¹⁰,Whetstine Johnathan R.¹⁸,Gerszten Robert E.⁵⁶,Kauppinen Sakari³⁴,Näär Anders M.¹²

Affiliation:

1. Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

2. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

3. Santaris Pharma, DK-2970 Hørsholm, Denmark.

4. Department of Haematology, Aalborg University Hospital, DK-2450 Copenhagen SV, Denmark.

5. Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.

6. Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

7. Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

8. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

9. RxGen Inc., 100 Deepwood Drive, Hamden, CT 06517, USA.

10. Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

11. Department of Cell and Developmental Biology, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, P. O. Box 24144, Doha, Qatar.

Abstract

Long-term treatment of obese, insulin-resistant nonhuman primates with a seed-targeting antimiR oligonucleotide against the microRNA-33 family derepresses hepatic expression of miR-33 targets, increases circulating HDL cholesterol, and has a clean safety profile.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference34 articles.

1. The functions of animal microRNAs

2. MicroRNAs

3. MicroRNAs: Target Recognition and Regulatory Functions

4. The expansion of the metazoan microRNA repertoire

5. Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

Cited by 112 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification of Important Genes Associated with the Development of Atherosclerosis;Current Gene Therapy;2024-02

2. Innovative Genoceuticals in Human Gene Therapy Solutions: Challenges and Safe Clinical Trials of Orphan Gene Therapy Products;Current Gene Therapy;2024-02

3. Comparison of interaction between antimiR and microRNA versus HDO-antimiR and microRNA by molecular dynamics simulation;Nucleosides, Nucleotides & Nucleic Acids;2024-01-11

4. Targeted Expression to Liver of an antimiR-33 Sponge as a Gene Therapy Strategy against Hypercholesterolemia: In Vitro Study;Current Issues in Molecular Biology;2023-08-24

5. Effects of miR-33 Deficiency on Metabolic and Cardiovascular Diseases: Implications for Therapeutic Intervention;International Journal of Molecular Sciences;2023-06-28