Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD-Reference-Cited by-同舟云学术

Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD

Published:2011-08-10 Issue:95 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lionel Anath C.¹²,Crosbie Jennifer³,Barbosa Nicole³,Goodale Tara³,Thiruvahindrapuram Bhooma¹,Rickaby Jessica¹,Gazzellone Matthew¹,Carson Andrew R.¹,Howe Jennifer L.¹,Wang Zhuozhi¹,Wei John¹,Stewart Alexandre F. R.⁴,Roberts Robert⁴,McPherson Ruth⁴,Fiebig Andreas⁵,Franke Andre⁵,Schreiber Stefan⁵⁶,Zwaigenbaum Lonnie⁷,Fernandez Bridget A.⁸,Roberts Wendy⁹,Arnold Paul D.¹⁰,Szatmari Peter¹,Marshall Christian R.¹,Schachar Russell³,Scherer Stephen W.¹²

Affiliation:

1. The Centre for Applied Genomics and Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

2. Department of Molecular Genetics and McLaughlin Centre, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

3. Department of Psychiatry, Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

4. University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada.

5. Institute for Clinical Molecular Biology, Christian-Albrechts-University and Biobank popgen, Kiel 24098, Germany.

6. Department of Internal Medicine, University of Kiel, Kiel 24118, Germany.

7. Department of Pediatrics, University of Alberta, Edmonton, Alberta T6B 2H3, Canada.

8. Disciplines of Genetics and Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada.

9. Autism Research Unit, Hospital for Sick Children and Bloorview Kids Rehab, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

10. Department of Psychiatry, and Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

Abstract

A high-resolution analysis of copy number variation in patients with ADHD reveals new gene associations, few de novo mutations, and overlap with genes implicated in other disorders such as autism.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference88 articles.

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