A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis-Reference-Cited by-同舟云学术

A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Published:2009-12-09 Issue:10 Volume:1 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Jagodic Maja¹,Colacios Celine²³,Nohra Rita¹,Dejean Anne S.²³,Beyeen Amennai Daniel¹,Khademi Mohsen¹,Casemayou Audrey²³,Lamouroux Lucille²³,Duthoit Christine²³,Papapietro Olivier²³,Sjöholm Louise¹,Bernard Isabelle²³,Lagrange Dominique²³,Dahlman Ingrid¹,Lundmark Frida⁴,Oturai Annette B.⁵,Soendergaard Helle B.⁵,Kemppinen Anu⁶,Saarela Janna⁶,Tienari Pentti J.⁷,Harbo Hanne F.⁸,Spurkland Anne⁹,Ramagopalan Sreeram V.¹⁰,Sadovnick Dessa A.¹¹,Ebers George C.¹⁰,Seddighzadeh Maria¹²,Klareskog Lars¹²,Alfredsson Lars¹³,Padyukov Leonid¹²,Hillert Jan⁴,Clanet Michel²³¹⁴,Edan Gilles¹⁵,Fontaine Bertrand¹⁶¹⁷¹⁸,Fournié Gilbert J.²³,Kockum Ingrid¹,Saoudi Abdelhadi²³,Olsson Tomas¹

Affiliation:

1. Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, S-17176 Stockholm, Sweden.

2. Institut National de la Santé et de la Recherche Médicale, U563, F-31000 Toulouse, France.

3. Université Toulouse III Paul Sabatier, F-31000 Toulouse, France.

4. Department of Clinical Neuroscience, Division of Neurology, Karolinska Institutet, S-17186 Stockholm, Sweden.

5. Danish Multiple Sclerosis Research Center, University of Copenhagen and Rigshospitalet, DK-2100 Copenhagen, Denmark.

6. Department of Molecular Medicine, Institute of Molecular Medicine Finland, National Public Health Institute, FIN-00290 Helsinki, Finland.

7. Department of Neurology, Helsinki University Central Hospital and Molecular Neurology Programme, Biomedicum, University of Helsinki, FIN-00290 Helsinki, Finland.

8. Department of Neurology, Oslo University Hospital Ullevål and University of Oslo, N-0407 Oslo, Norway.

9. Department of Anatomy, Institute of Basal Medical Science, University of Oslo, N-0317 Oslo, Norway.

10. Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, OX3 7BN Oxford, UK.

11. Department of Medical Genetics and Faculty of Medicine, Division of Neurology, University of British Columbia, V6T 2B5 Vancouver, British Columbia, Canada.

12. Department of Medicine, Rheumatology Unit, Karolinska Institutet, S-17176 Stockholm, Sweden.

13. Institute of Environmental Medicine, Karolinska Institutet, S-17177 Stockholm, Sweden.

14. Hôpital Purpan, Service de Neurologie, F-31300 Toulouse, France.

15. CHRU de Pontchaillou, Service de Neurologie, F-35033 Rennes Cedex 09, France.

16. Institut National de la Santé et de la Recherche Médicale, UMR 975, F-75013 Paris, France.

17. Université Pierre et Marie Curie-Paris 6, F-75013 Paris, France.

18. Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, F-75013 Paris, France.

Abstract

VAV1 plays a role in regulating proinflammatory cytokines, which underlie the susceptibility for developing experimental autoimmune encephalomyelitis and multiple sclerosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Progressive Multifocal Leukoencephalopathy after Natalizumab Monotherapy

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5. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

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