Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome-Reference-Cited by-同舟云学术

Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome

Published:2014-10 Issue:256 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bjornsson Hans T.¹²,Benjamin Joel S.¹³,Zhang Li¹,Weissman Jacqueline¹⁴,Gerber Elizabeth E.¹,Chen Yi-Chun¹,Vaurio Rebecca G.⁴,Potter Michelle C.⁵,Hansen Kasper D.¹⁶,Dietz Harry C.¹⁷⁸

Affiliation:

1. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

4. Kennedy Krieger Institute, Baltimore, MD 21205, USA.

5. Brain Science Institute, Neurology Department, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

6. Department of Biostatistics, Bloomberg School of Public Health, Baltimore, MD 21205, USA.

7. Division of Pediatric Cardiology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

8. Howard Hughes Medical Institute, Baltimore, MD 21205, USA.

Abstract

A neurogenesis defect in a mouse model of Kabuki syndrome can be ameliorated postnatally using histone deacetylase inhibitors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

1. Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome;Ng S. B.;Nat. Genet.,2010

2. Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome;Lederer D.;Am. J. Hum. Genet.,2012

3. KDM6A point mutations cause Kabuki syndrome;Miyake N.;Hum. Mutat.,2013

4. Temporal features of adult neurogenesis: Differences and similarities across mammalian species;Brus M.;Front. Neurosci.,2013

5. Are New Neurons Formed in the Brains of Adult Mammals?

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