Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2-Reference-Cited by-同舟云学术

Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2

Published:2010-11-03 Issue:56 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Scott-Van Zeeland Ashley A.¹²³,Abrahams Brett S.⁴,Alvarez-Retuerto Ana I.⁴⁵,Sonnenblick Lisa I.⁴,Rudie Jeffrey D.²,Ghahremani Dara⁶,Mumford Jeanette A.⁷,Poldrack Russell A.⁷,Dapretto Mirella⁵⁶⁸,Geschwind Daniel H.⁴⁵,Bookheimer Susan Y.¹⁵⁶⁷

Affiliation:

1. Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

2. Neuroscience Interdepartmental Program, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

3. Scripps Translational Science Institute, La Jolla, CA 92037, USA.

4. Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

5. Center for Autism Research and Treatment, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

6. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

7. Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

8. Ahmanson-Lovelace Brain Mapping Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Abstract

Children who carry one variant of a brain protein associated with autism exhibit fewer long-range connections between the prefrontal cortex and more posterior brain regions.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference40 articles.

1. B. S. Abrahams D. H. Geschwind Genetics of autism in Human Genetics: Problems and Approaches M. R. Speicher S. E. Antonarakis A. G. Motulsky Eds. (Springer-Verlag Heidelberg 2010).

2. Cntnap2 is disrupted in a family with gilles de la tourette syndrome and obsessive compulsive disorder

3. Recessive Symptomatic Focal Epilepsy and Mutant Contactin-Associated Protein-like 2

4. Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene

5. A Common Genetic Variant in the Neurexin Superfamily Member CNTNAP2 Increases Familial Risk of Autism

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