Extended Survival of Glioblastoma Patients After Chemoprotective HSC Gene Therapy-Reference-Cited by-同舟云学术

Extended Survival of Glioblastoma Patients After Chemoprotective HSC Gene Therapy

Published:2012-05-09 Issue:133 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Adair Jennifer E.¹,Beard Brian C.¹²,Trobridge Grant D.³,Neff Tobias⁴⁵,Rockhill Jason K.⁶⁷,Silbergeld Daniel L.⁶⁸,Mrugala Maciej M.⁶⁹,Kiem Hans-Peter¹²⁸

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

2. Department of Medicine, University of Washington, Seattle, WA 98195, USA.

3. Department of Pharmaceutical Sciences, Washington State University, Pullman, WA 99164, USA.

4. Dana-Farber/Children’s Hospital Cancer Center, Boston, MA 02115, USA.

5. Harvard Medical School, Boston, MA 02115, USA.

6. Department of Neurosurgery, University of Washington, Seattle, WA 98195, USA.

7. Department of Radiation Oncology, University of Washington, Seattle, WA 98195, USA.

8. Department of Pathology, University of Washington, Seattle, WA 98195, USA.

9. Department of Neurology, University of Washington, Seattle, WA 98195, USA.

Abstract

Gene therapy using P140K-modified hematopoietic progenitor cells is chemoprotective, enabling glioblastoma patients to withstand myelotoxic doses of chemotherapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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1. Phase I Trial of Carmustine Plus O6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

2. Phase I Trial of Temozolomide PlusO6-Benzylguanine for Patients With Recurrent or Progressive Malignant Glioma

3. Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma

4. Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients

5. Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates

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