Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

Author:

Chan Denise A.12,Sutphin Patrick D.3,Nguyen Phuong1,Turcotte Sandra4,Lai Edwin W.1,Banh Alice1,Reynolds Gloria E.2,Chi Jen-Tsan5,Wu Jason6,Solow-Cordero David E.6,Bonnet Muriel7,Flanagan Jack U.7,Bouley Donna M.8,Graves Edward E.1,Denny William A.7,Hay Michael P.7,Giaccia Amato J.1

Affiliation:

1. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Department of Radiation Oncology, University of California, San Francisco, CA 94143, USA.

3. Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

4. Université de Moncton, Moncton, New Brunswick E1A 3E9, Canada.

5. Institute for Genome Sciences and Policy, Department of Molecular Genetics and Microbiology, Duke Medical Center, Durham, NC 27708, USA.

6. High-Throughput Bioscience Center, Stanford University School of Medicine, Stanford, CA 94305, USA.

7. Auckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

8. Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

A screen identifies a drug that specifically kills glycolysis-dependent cancer cells by inhibiting glucose uptake.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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