An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model-Reference-Cited by-同舟云学术

An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model

Published:2014-04-16 Issue:232 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Krumm Stefanie A.¹,Yan Dan¹,Hovingh Elise S.²,Evers Taylor J.³,Enkirch Theresa²⁴,Reddy G. Prabhakar³,Sun Aiming³,Saindane Manohar T.³,Arrendale Richard F.³,Painter George³⁵,Liotta Dennis C.⁶,Natchus Michael G.³,von Messling Veronika²⁴,Plemper Richard K.¹⁷

Affiliation:

1. Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.

2. Veterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, 63225 Langen, Germany.

3. Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.

4. Emerging Infectious Disease Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore.

5. Drug Innovation Ventures at Emory, Atlanta, GA 30309, USA.

6. Department of Chemistry, Emory University, Atlanta, GA 30322, USA.

7. Department of Pediatrics, Emory University, Atlanta, GA 30322, USA.

Abstract

An orally available, shelf-stable pan-morbillivirus inhibitor targeting a viral polymerase effectively treats ferrets infected with a lethal dose of a measles-like virus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference45 articles.

1. The pathogenesis of measles

2. Measles Immune Suppression: Lessons from the Macaque Model

3. Measles virus-induced suppression of immune responses

4. Tropism illuminated: Lymphocyte-based pathways blazed by lethal morbillivirus through the host immune system

5. The Clinical Significance of Measles: A Review

Cited by 48 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets;2023-09-02

2. Infection of ferrets with wild type-based recombinant canine distemper virus overwhelms the immune system and causes fatal systemic disease;mSphere;2023-08-24

3. Biomolecular Analysis of Canine Distemper Virus Strains in Two Domestic Ferrets (Mustela putorius furo);Veterinary Sciences;2023-05-26

4. Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus;Nature Microbiology;2023-05-04

5. Molecular Modeling Identification of Key Secondary Metabolites from Xylopia aethiopica as Promising Therapeutics Targeting Essential Measles Viral Proteins;Evidence-Based Complementary and Alternative Medicine;2023-02-09