Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients

Author:

Adair Robert A.1,Roulstone Victoria2,Scott Karen J.1,Morgan Ruth1,Nuovo Gerard J.3,Fuller Martin4,Beirne Deborah1,West Emma J.1,Jennings Victoria A.1,Rose Ailsa1,Kyula Joan2,Fraser Sheila1,Dave Rajiv1,Anthoney David A.1,Merrick Alison1,Prestwich Robin1,Aldouri Amer1,Donnelly Oliver1,Pandha Hardev5,Coffey Matt6,Selby Peter1,Vile Richard7,Toogood Giles1,Harrington Kevin2,Melcher Alan A.1

Affiliation:

1. Leeds Institute of Molecular Medicine, St. James’s University Hospital, Leeds LS9 7TF, UK.

2. Institute of Cancer Research, Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London SW3 6JB, UK.

3. Comprehensive Cancer Centre, Ohio State University, Columbus, OH 43210, USA.

4. Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

5. Postgraduate Medical School, University of Surrey, Guildford GU2 7WG, UK.

6. Oncolytics Biotech Inc., Calgary, Alberta T2N 1X7, Canada.

7. Molecular Medicine Program and Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

Abstract

Oncolytic reovirus is carried by cells to tumors and protected from neutralizing antibodies in the circulation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference26 articles.

1. Design of virotherapy for effective tumor treatment.;Garcia-Aragoncillo E.;Curr. Opin. Mol. Ther.,2010

2. Oncolytic viruses: a novel form of immunotherapy

3. Clinical development directions in oncolytic viral therapy

4. OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma

5. Targeted and armed oncolytic poxviruses for cancer: The lead example of JX-594.;Breitbach C. J.;Curr. Pharm. Biotechnol.,2011

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