Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients-Reference-Cited by-同舟云学术

Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients

Published:2012-06-13 Issue:138 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Adair Robert A.¹,Roulstone Victoria²,Scott Karen J.¹,Morgan Ruth¹,Nuovo Gerard J.³,Fuller Martin⁴,Beirne Deborah¹,West Emma J.¹,Jennings Victoria A.¹,Rose Ailsa¹,Kyula Joan²,Fraser Sheila¹,Dave Rajiv¹,Anthoney David A.¹,Merrick Alison¹,Prestwich Robin¹,Aldouri Amer¹,Donnelly Oliver¹,Pandha Hardev⁵,Coffey Matt⁶,Selby Peter¹,Vile Richard⁷,Toogood Giles¹,Harrington Kevin²,Melcher Alan A.¹

Affiliation:

1. Leeds Institute of Molecular Medicine, St. James’s University Hospital, Leeds LS9 7TF, UK.

2. Institute of Cancer Research, Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London SW3 6JB, UK.

3. Comprehensive Cancer Centre, Ohio State University, Columbus, OH 43210, USA.

4. Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

5. Postgraduate Medical School, University of Surrey, Guildford GU2 7WG, UK.

6. Oncolytics Biotech Inc., Calgary, Alberta T2N 1X7, Canada.

7. Molecular Medicine Program and Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

Abstract

Oncolytic reovirus is carried by cells to tumors and protected from neutralizing antibodies in the circulation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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