Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma-Reference-Cited by-同舟云学术

Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma

Published:2011-11-09 Issue:108 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bresler Scott C.¹²³,Wood Andrew C.⁴⁵,Haglund Elizabeth A.⁴⁵,Courtright Joshua⁴⁵,Belcastro Lili T.⁴⁵,Plegaria Jefferson S.⁴⁵,Cole Kristina⁴⁵,Toporovskaya Yana⁴⁵,Zhao Huaqing⁵⁶,Carpenter Erica L.⁴⁵,Christensen James G.⁷,Maris John M.⁴⁵⁸,Lemmon Mark A.¹²,Mossé Yaël P.⁴⁵

Affiliation:

1. Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104–6059, USA.

2. Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Medical Scientist Training Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Division of Oncology and Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

5. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Biostatistics and Data Management Core, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

7. Department of Cancer Research, Pfizer Global Research and Development, La Jolla Laboratories, La Jolla, CA 92121, USA.

8. Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Neuroblastoma sensitivity to crizotinib depends on the ATP-binding affinity of ALK variants, suggesting that higher doses may overcome resistance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference38 articles.

1. SPECIAL PATTERN OF WIDESPREAD NEUROBLASTOMA WITH A FAVOURABLE PROGNOSIS

2. Late effects in survivors of tandem peripheral blood stem cell transplant for high-risk neuroblastoma

3. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

4. Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

5. Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

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