PGC-1 α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

Author:

Zheng Bin1,Liao Zhixiang1,Locascio Joseph J.2,Lesniak Kristen A.3,Roderick Sarah S.1,Watt Marla L.3,Eklund Aron C.14,Zhang-James Yanli5,Kim Peter D.6,Hauser Michael A.7,Grünblatt Edna8,Moran Linda B.9,Mandel Silvia A.10,Riederer Peter8,Miller Renee M.11,Federoff Howard J.12,Wüllner Ullrich13,Papapetropoulos Spyridon1415,Youdim Moussa B.1016,Cantuti-Castelvetri Ippolita2,Young Anne B.2,Vance Jeffery M.17,Davis Richard L.18,Hedreen John C.19,Adler Charles H.20,Beach Thomas G.21,Graeber Manuel B.22,Middleton Frank A.18,Rochet Jean-Christophe3,Scherzer Clemens R.123,

Affiliation:

1. Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, 65 Landsdowne Street, Suite 307A, Cambridge, MA 02139, USA.

2. Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

3. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.

4. Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.

5. Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

6. Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

7. Department of Medicine, Duke University, Durham, NC 27708, USA.

8. Clinical Neurochemistry, National Parkinson Foundation Centre of Excellence Research Laboratory, University of Würzburg, 97070 Würzburg, Germany.

9. North Wembley, Middlesex HAO 3QJ, UK.

10. Eve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases, Technion-Faculty of Medicine, Haifa 31096, Israel.

11. Center for Neural Development and Disease, University of Rochester, Rochester, NY 14620, USA.

12. Department of Neurology, Georgetown University Medical Center, Washington, DC 20007, USA.

13. Department of Neurology, Friedrich-Wilhelms-University Bonn, UKB, 53105 Bonn, Germany.

14. Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

15. Allergan, Irvine, CA 92623-9534, USA.

16. Department of Biology, Yonsei World Central University, Seoul 120-749, South Korea.

17. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

18. Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

19. Harvard Brain Tissue Resource Center, Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA.

20. Mayo Division of Movement Disorders, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.

21. W. H. Civin Laboratory of Neuropathology, Sun Health Research Institute, Sun City, AZ 85259, USA.

22. The Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales 2050, Australia.

23. Harvard NeuroDiscovery Center Biomarker Program, Cambridge, MA 02139, USA.

Abstract

Abnormal expression of genes for energy regulation in Parkinson’s disease patients identifies a master regulator as a possible therapeutic target for early intervention.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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