Rational design of small molecules as vaccine adjuvants-Reference-Cited by-同舟云学术

Rational design of small molecules as vaccine adjuvants

Published:2014-11-19 Issue:263 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wu Tom Y.-H.¹,Singh Manmohan²,Miller Andrew T.¹,De Gregorio Ennio³,Doro Francesco³,D’Oro Ugo³,Skibinski David A. G.³,Mbow M. Lamine¹,Bufali Simone³,Herman Ann E.¹,Cortez Alex¹,Li Yongkai¹,Nayak Bishnu P.³,Tritto Elaine³,Filippi Christophe M.¹,Otten Gillis R.²,Brito Luis A.²,Monaci Elisabetta³,Li Chun¹,Aprea Susanna³,Valentini Sara³,Calabrό Samuele³,Laera Donatello³,Brunelli Brunella³,Caproni Elena³,Malyala Padma²,Panchal Rekha G.⁴,Warren Travis K.⁴,Bavari Sina⁴,O’Hagan Derek T.²,Cooke Michael P.¹,Valiante Nicholas M.²

Affiliation:

1. The Genomics Institute of Novartis Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

2. Novartis Vaccines, 45 Sidney Street, Cambridge, MA 02139, USA.

3. Novartis Vaccines, Via Florentina 1, 53100 Siena, Italy.

4. U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Abstract

Small-molecule immune potentiators can be engineered to be potent adjuvants with localized innate immune activation and short in vivo residence times.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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