Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human Antibody

Author:

Dao Tao1,Yan Su2,Veomett Nicholas13,Pankov Dmitry1,Zhou Liang2,Korontsvit Tatyana1,Scott Andrew1,Whitten Joseph1,Maslak Peter1,Casey Emily1,Tan Taochao2,Liu Hong2,Zakhaleva Victoria1,Curcio Michael1,Doubrovina Ekaterina1,O’Reilly Richard J.13,Liu Cheng2,Scheinberg David A.13

Affiliation:

1. Molecular Pharmacology and Chemistry Program, Immunology Program, Departments of Medicine, Pediatrics, Pathology, and Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

2. Eureka Therapeutics, Emeryville, CA 94608, USA.

3. Weill Cornell Medical College, New York, NY 10021, USA.

Abstract

A therapeutic monoclonal antibody specific for the intracellular oncoprotein Wilms tumor 1 treats human leukemias in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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