A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models-Reference-Cited by-同舟云学术

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

Published:2021-09-29 Issue:613 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yu Xufen¹²^ORCID,Li Dongxu³⁴^ORCID,Kottur Jithesh¹²^ORCID,Shen Yudao¹²,Kim Huen Suk¹²^ORCID,Park Kwang-Su¹²^ORCID,Tsai Yi-Hsuan³^ORCID,Gong Weida³,Wang Jun³⁴,Suzuki Kyogo³,Parker Joel³⁵^ORCID,Herring Laura⁶^ORCID,Kaniskan H. Ümit¹²^ORCID,Cai Ling³⁵,Jain Rinku²,Liu Jing¹²^ORCID,Aggarwal Aneel K²^ORCID,Wang Gang Greg³⁴⁶^ORCID,Jin Jian¹²^ORCID

Affiliation:

1. Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

2. Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

3. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

5. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

WDR5-degrader-E3 ligase ternary complex structure–based design led to a highly effective WDR5 degrader with robust in vivo antitumor activities.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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