An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo

Author:

Cao Duo-Yao1ORCID,Giani Jorge F.12ORCID,Veiras Luciana C.1ORCID,Bernstein Ellen A.1ORCID,Okwan-Duodu Derick12ORCID,Ahmed Faizan1ORCID,Bresee Catherine3ORCID,Tourtellotte Warren G.124,Karumanchi S. Ananth5ORCID,Bernstein Kenneth E.12ORCID,Khan Zakir12ORCID

Affiliation:

1. Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

2. Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

3. Biostatistics and Bioinformatics Core, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

4. Department of Neurology, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

5. Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.

Abstract

ACE inhibitor treatment reduces human and mouse neutrophil function.

Funder

National Institutes of Health

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

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3. Angiotensin‐converting enzyme is required for normal myelopoiesis

4. Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-κB activation and monocyte chemoattractant protein-1 synthesis;Ruiz-Ortega M.;J. Immunol.,1998

5. Mice with Enhanced Macrophage Angiotensin-Converting Enzyme Are Resistant to Melanoma

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