Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

Author:

D’Agnillo Felice1ORCID,Walters Kathie-Anne2,Xiao Yongli3,Sheng Zong-Mei3,Scherler Kelsey2ORCID,Park Jaekeun3ORCID,Gygli Sebastian3,Rosas Luz Angela3ORCID,Sadtler Kaitlyn4ORCID,Kalish Heather5ORCID,Blatti Charles A.6ORCID,Zhu Ruoqing7ORCID,Gatzke Lisa6ORCID,Bushell Colleen6ORCID,Memoli Matthew J.8ORCID,O’Day Steven J.9,Fischer Trevan D.9ORCID,Hammond Terese C.9,Lee Raymond C.10,Cash J. Christian10,Powers Matthew E.10ORCID,O’Keefe Grant E.11ORCID,Butnor Kelly J.12,Rapkiewicz Amy V.13ORCID,Travis William D.14,Layne Scott P.9ORCID,Kash John C.3ORCID,Taubenberger Jeffery K.3ORCID

Affiliation:

1. Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

2. Institute for Systems Biology, Seattle, WA, USA.

3. Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

4. Section on Immunoengineering, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.

5. Bioengineering and Physical Sciences Shared Resource, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.

6. National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

7. Department of Statistics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

8. Clinical Studies Unit, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

9. Saint John’s Cancer Institute, Santa Monica, CA, USA.

10. Division of Cardiothoracic Surgery, USC Keck School of Medicine, Los Angeles, CA, USA.

11. Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA, USA.

12. Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT, USA.

13. Department of Pathology, New York University Long Island School of Medicine, Mineola, NY, USA.

14. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Abstract

Lung epithelial and endothelial cell damage and defective lung tissue repair contribute to fatal COVID-19.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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