Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

Author:

Yang Yoon Mee12ORCID,Noureddin Mazen13ORCID,Liu Cheng4,Ohashi Koichiro1,Kim So Yeon1ORCID,Ramnath Divya5ORCID,Powell Elizabeth E.67,Sweet Matthew J.5ORCID,Roh Yoon Seok18,Hsin I-Fang1,Deng Nan9,Liu Zhenqiu9,Liang Jiurong11011ORCID,Mena Edward12ORCID,Shouhed Daniel13,Schwabe Robert F.14ORCID,Jiang Dianhua11011ORCID,Lu Shelly C.1,Noble Paul W.110,Seki Ekihiro111ORCID

Affiliation:

1. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

2. College of Pharmacy, Kangwon National University, Chuncheon 24341, South Korea.

3. Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

4. Department of Infectious Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.

5. Institute for Molecular Bioscience (IMB) and IMB Centre for Inflammation and Disease Research, University of Queensland, Brisbane, Queensland 4072, Australia.

6. Centre for Liver Disease Research, University of Queensland, Brisbane, Queensland, Australia.

7. Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.

8. Department of Pharmacy, Chungbuk National University College of Pharmacy, Cheongju, Chungbuk 28160, South Korea.

9. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

10. Women's Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

11. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

12. California Liver Research Institute, Pasadena, CA 91105, USA.

13. Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

14. Department of Medicine, Columbia University, New York, NY 10032, USA.

Abstract

Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.

Funder

National Institute on Alcohol Abuse and Alcoholism

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

American Liver Foundation

American Association for the Study of Liver Diseases

Cedars-Sinai Medical Center

Kangwon National University

National Research Foundation of Korea

Colleges and universities in Shanghai

National Natural Science Foundation of China

National Health and Medical Research Council of Australia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference49 articles.

1. Liver fibrosis

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3. Deaths: Final data for 2010;Murphy S. L.;Natl. Vital Stat. Rep.,2013

4. Novel drug targets for idiopathic pulmonary fibrosis;Sgalla G.;Expert Rev. Respir. Med.,2016

5. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

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