Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway-Reference-Cited by-同舟云学术

Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway

Published:2018-10-10 Issue:462 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wang Peng¹^ORCID,Luo Man-Li²^ORCID,Song Erwei²,Zhou Zhanmei¹,Ma Tongtong¹^ORCID,Wang Jun¹^ORCID,Jia Nan¹,Wang Guobao¹,Nie Sheng¹,Liu Youhua¹,Hou FanFan¹^ORCID

Affiliation:

1. Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou 510515, China.

2. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.

Abstract

A human long noncoding RNA targeting the TGF-β/Smad pathway reduced fibrogenesis in mouse models of renal fibrosis.

Funder

The National Science Foundation of China

the National Key Technology Support Program of China

the Major International (Regional) Joint Research Project of National Natural Science Foundation of China

the Foundation for Innovation Research Groups of the National Natural Science Foundation of China

the Major Scientific and Technological Planning Project of Guangzhou

Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference59 articles.

1. Chronic Kidney Disease Progression

2. TGF-ß Signaling in Renal Disease

3. Overview of the cellular and molecular basis of kidney fibrosis

4. Cellular and molecular mechanisms of renal fibrosis

5. Renal fibrosis: novel insights into mechanisms and therapeutic targets

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