Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs-Reference-Cited by-同舟云学术

Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs

Published:2019-01-16 Issue:475 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sharma Ruchi¹^ORCID,Khristov Vladimir²^ORCID,Rising Aaron²^ORCID,Jha Balendu Shekhar¹^ORCID,Dejene Roba¹,Hotaling Nathan¹,Li Yichao³^ORCID,Stoddard Jonathan⁴,Stankewicz Casey⁵,Wan Qin²,Zhang Connie²,Campos Mercedes Maria⁶^ORCID,Miyagishima Kiyoharu J.²,McGaughey David⁷^ORCID,Villasmil Rafael⁸^ORCID,Mattapallil Mary⁹,Stanzel Boris¹⁰,Qian Haohua³^ORCID,Wong Wai¹¹^ORCID,Chase Lucas⁵,Charles Steve¹²,McGill Trevor⁴,Miller Sheldon²^ORCID,Maminishkis Arvydas²^ORCID,Amaral Juan¹³^ORCID,Bharti Kapil¹^ORCID

Affiliation:

1. Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD 20892, USA.

2. Section on Epithelial and Retinal Physiology and Disease, National Eye Institute, NIH, Bethesda, MD 20892, USA.

3. Visual Function Core, National Eye Institute, NIH, Bethesda, MD 20892, USA.

4. Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.

5. Cellular Dynamics International Inc. (a FUJIFILM company), Madison, WI 53711, USA.

6. Histology Core, National Eye Institute, NIH, Bethesda, MD 20892, USA.

7. Ophthalmic Genetics and Visual Functional Branch, National Eye Institute, NIH, Bethesda, MD 20892, USA.

8. Flow Cytometry Core, National Eye Institute, NIH, Bethesda, MD 20892, USA.

9. Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA.

10. Macula Center Saar, Sulzbach Knappschaft Eye Clinic, Sulzbach/Saar 66280, Germany.

11. Unit on Neuron-Glia Interactions in Retinal Disease, National Eye Institute, NIH, Bethesda, MD 20892, USA.

12. Charles Retina Institute, Germantown, TN 38138, USA.

13. Office of Scientific Director, National Eye Institute, NIH, Bethesda, MD 20892, USA.

Abstract

A retinal pigment epithelial patch derived from mutation-free pluripotent stem cells shows therapeutic effects in rats and pigs.

Funder

NIH Office of the Director

National Eye Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference54 articles.

1. Cell-Based Therapeutics: The Next Pillar of Medicine

2. Looking into the future: Using induced pluripotent stem cells to build two and three dimensional ocular tissue for cell therapy and disease modeling

3. Autologous Translocation of the Choroid and Retinal Pigment Epithelium in Patients with Geographic Atrophy

4. A Free Retinal Pigment Epithelium–Choroid Graft in Patients With Exudative Age-Related Macular Degeneration: Results up to 7 Years

5. Embryonic stem cell trials for macular degeneration: a preliminary report

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