Patients with autism spectrum disorders display reproducible functional connectivity alterations

Author:

Holiga Štefan1ORCID,Hipp Joerg F.1ORCID,Chatham Christopher H.1,Garces Pilar1ORCID,Spooren Will1,D’Ardhuy Xavier Liogier1,Bertolino Alessandro12,Bouquet Céline1,Buitelaar Jan K.3ORCID,Bours Carsten3ORCID,Rausch Annika3,Oldehinkel Marianne34,Bouvard Manuel5ORCID,Amestoy Anouck5ORCID,Caralp Mireille6,Gueguen Sonia7,Ly-Le Moal Myriam8ORCID,Houenou Josselin910,Beckmann Christian F.3,Loth Eva11,Murphy Declan11ORCID,Charman Tony11ORCID,Tillmann Julian1112ORCID,Laidi Charles9,Delorme Richard1314,Beggiato Anita1314ORCID,Gaman Alexandru9ORCID,Scheid Isabelle9ORCID,Leboyer Marion9,d’Albis Marc-Antoine910,Sevigny Jeff1ORCID,Czech Christian1ORCID,Bolognani Federico115,Honey Garry D.1,Dukart Juergen11617ORCID

Affiliation:

1. Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

2. Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari ‘Aldo Moro’, 70121 Bari, Italy.

3. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen Medical center, Nijmegen 6525 EN, Netherlands.

4. Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Clayton, VIC 3800, Australia.

5. Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Hôpital Charles Perrens Bordeaux, 33076 Bordeaux, France.

6. INSERM, National Biobank Infrastructure, 75013 Paris, France.

7. INSERM, Clinical Research Department, 75014 Paris, France.

8. Institut Roche, 92100 Boulogne-Billancourt, France.

9. Hôpitaux Universitaires Mondor, DHU PePSY, Pôle de psychiatrie, Faculté de Médecine, Université Paris Est, INSERM U955, IMRB, Equipe 15, Psychiatrie Translationnelle, Fondation FondaMental, 94000 Créteil, France.

10. NeuroSpin, UNIACT Lab, Psychiatry Team, CEA Saclay, 91191 Gif-Sur-Yvette, France.

11. Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

12. Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, 1010 Vienna, Austria.

13. APHP, Robert Debré Hospital, Child and Adolescent Psychiatry Department, Paris, France.

14. Pasteur Institute, 75019 Paris, France.

15. Therachon AG, Aeschenvorstadt 36, 4051 Basel, Switzerland.

16. Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, 52428 Jülich, Germany.

17. Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, 40223 Düsseldorf, Germany.

Abstract

Functional connectivity alterations are conserved in multiple cohorts of patients with autism spectrum disorder.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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