Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus-Reference-Cited by-同舟云学术

Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus

Published:2019-01-16 Issue:475 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chan Rita¹^ORCID,Buckley Peter T.²,O’Malley Aidan¹^ORCID,Sause William E.¹^ORCID,Alonzo Francis¹,Lubkin Ashira¹^ORCID,Boguslawski Kristina M.¹^ORCID,Payne Angela²,Fernandez Jeffrey²,Strohl William R.²,Whitaker Brian²,Lynch Anthony Simon²,Torres Victor J.¹^ORCID

Affiliation:

1. Department of Microbiology, New York University School of Medicine, Alexandria Center for Life Science, 430 East 29th Street, New York, NY 10016, USA.

2. Janssen Research & Development, 1400 McKean Road, Spring House, PA, 19477, USA.

Abstract

Small protein biologics called centyrins can be engineered to combat the toxicity caused by systemic Staphylococcus aureus infection.

Funder

National Institute of Allergy and Infectious Diseases

Janssen Research and Development

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference54 articles.

1. Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era