Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain

Author:

Aoyagi Atsushi12ORCID,Condello Carlo13ORCID,Stöhr Jan134,Yue Weizhou1ORCID,Rivera Brianna M.1ORCID,Lee Joanne C.1,Woerman Amanda L.13ORCID,Halliday Glenda5ORCID,van Duinen Sjoerd6ORCID,Ingelsson Martin7,Lannfelt Lars7,Graff Caroline89,Bird Thomas D.1011,Keene C. Dirk12ORCID,Seeley William W.313,DeGrado William F.114ORCID,Prusiner Stanley B.1315ORCID

Affiliation:

1. Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Daiichi Sankyo Co. Ltd., Tokyo 140-8710, Japan.

3. Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.

4. AC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, Switzerland.

5. NeuRA and School of Medical Sciences, University of New South Wales, and Brain and Mind Centre, University of Sydney, Sydney, NSW 2052, Australia.

6. Leiden University Medical Center, Leiden, Netherlands.

7. Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, 751 85 Uppsala, Sweden.

8. Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden.

9. Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital, Solna, Sweden.

10. Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.

11. Department of Neurology, University of Washington, Seattle, WA 98195, USA.

12. Department of Neuropathology, University of Washington School of Medicine, Seattle, WA 98195, USA.

13. Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

14. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.

15. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

Cellular assays reveal a decline in Aβ and tau pathological conformers in Alzheimer’s disease brain samples.

Funder

National Institutes of Health

National Institute on Aging

Alzheimer’s Association

Rainwater Charitable Foundation

Swedish Brain Power

Karolinska Institutet StratNeuro

Stockholm County Council Core Facility Funding

National Health and Medical Research Council of Australia

Dana Foundation

Glenn Foundation for Medical Research

Henry M. Jackson Foundation

Sherman Fairchild Foundation

Daiichi-Sankyo

Nancy and Buster Alvord Endowment

Bluefield Project

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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