Tuberculosis following PD-1 blockade for cancer immunotherapy

Author:

Barber Daniel L.1ORCID,Sakai Shunsuke1ORCID,Kudchadkar Ragini R.2,Fling Steven P.34,Day Tracey A.5ORCID,Vergara Julie A.5ORCID,Ashkin David6ORCID,Cheng Jonathan H.7,Lundgren Lisa M.4ORCID,Raabe Vanessa N.8ORCID,Kraft Colleen S.9,Nieva Jorge J.7ORCID,Cheever Martin A.34ORCID,Nghiem Paul T.10ORCID,Sharon Elad11ORCID

Affiliation:

1. T Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

2. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

4. Cancer Immunotherapy Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

5. Clinical Immunology Group, Infectious Disease Research Institute, Seattle, WA 98102, USA.

6. Division of Infectious Diseases and Global Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA.

7. Norris Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.

8. Division of Infectious Diseases, Emory University, Atlanta, GA 30322, USA.

9. Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, USA.

10. Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

11. Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD 20892, USA.

Abstract

Increased Mtb-specific T H 1 responses precede tuberculosis associated with PD-1 blockade.

Funder

National Cancer Institute

Merck

NIAID Intramural Research Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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