Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome

Author:

Li Xiao-Kun1ORCID,Lu Qing-Bin2ORCID,Chen Wei-Wei3ORCID,Xu Wen3ORCID,Liu Rong4ORCID,Zhang Shao-Fei1,Du Juan2,Li Hao1,Yao Ke5,Zhai Di5,Zhang Pan-He1,Xing Bo1,Cui Ning6ORCID,Yang Zhen-Dong6ORCID,Yuan Chun6,Zhang Xiao-Ai1ORCID,Xu Zhe3ORCID,Cao Wu-Chun17ORCID,Hu Zeping5ORCID,Liu Wei178ORCID

Affiliation:

1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dongda Street, Fengtai District, Beijing 100071, P. R. China.

2. Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing 100191, P. R. China.

3. The 302 Hospital, People’s Liberation Army, No. 100, West 4th Ring Road, Fengtai District, Beijing 100039, P. R. China.

4. School of Basic Medical Sciences, Wuhan University School of Medicine, 185 Donghu Street, Wuhan 430071, P. R. China.

5. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, P. R. China.

6. The 154 Hospital, People’s Liberation Army, 104 Nan-Hu Road, Shihe District, Xinyang 464000, P. R. China.

7. School of Public Health, Shandong University, Jinan 250012, P.R. China.

8. Microbiology and Epidemiology, Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Diseases, Beijing, P. R. China.

Abstract

Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People’s Republic of China

Tsinghua University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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