Shaping of infant B cell receptor repertoires by environmental factors and infectious disease

Author:

Nielsen Sandra C. A.1ORCID,Roskin Krishna M.123ORCID,Jackson Katherine J. L.14ORCID,Joshi Shilpa A.1ORCID,Nejad Parastu1,Lee Ji-Yeun1,Wagar Lisa E.5ORCID,Pham Tho D.16,Hoh Ramona A.1ORCID,Nguyen Khoa D.1ORCID,Tsunemoto Hannah Y.1ORCID,Patel Sonal B.1,Tibshirani Robert78ORCID,Ley Catherine9ORCID,Davis Mark M.510ORCID,Parsonnet Julie911ORCID,Boyd Scott D.1ORCID

Affiliation:

1. Department of Pathology, Stanford University, Stanford, CA 94305, USA.

2. Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.

3. Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

4. Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.

5. Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.

6. Stanford Blood Center, Palo Alto, CA 94304, USA.

7. Department of Biomedical Data Sciences, Stanford University, Stanford, CA 94305, USA.

8. Department of Statistics, Stanford University, Stanford, CA 94305, USA.

9. Department of Medicine, Stanford University, Stanford, CA 94305, USA.

10. Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

11. Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA.

Abstract

Distinct environmental exposures are associated with the maturation of antibody types in early childhood.

Funder

NIH Office of the Director

Child Health Research Institute and the Stanford NIH-NCATS-CTSA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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