A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice-Reference-Cited by-同舟云学术

A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice

Published:2019-06-26 Issue:498 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chan Kitti Wing Ki¹²^ORCID,Watanabe Satoru¹^ORCID,Jin Jocelyn Y.¹,Pompon Julien¹³,Teng Don⁴,Alonso Sylvie²⁵,Vijaykrishna Dhanasekaran¹⁴^ORCID,Halstead Scott B.⁶,Marzinek Jan K.⁷,Bond Peter J.⁷,Burla Bo⁸^ORCID,Torta Federico⁸,Wenk Markus R.⁸,Ooi Eng Eong¹²^ORCID,Vasudevan Subhash G.¹²^ORCID

Affiliation:

1. Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.

2. Department of Microbiology and Immunology, 5 Science Drive 2, Singapore 117545, Singapore.

3. MIVEGEC, UMR IRD 224-CNRS5290 Université de Montpellier, Montpellier, France.

4. Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia.

5. Immunology Programme, Life Science Institute, National University of Singapore, Singapore 117456, Singapore.

6. Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20817, USA.

7. Bioinformatics Institute (A*STAR), 30 Biopolis St., Singapore 138671, Singapore.

8. Singapore Lipidomics Incubator (SLING), Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

Abstract

The T164S mutation in the NS1 protein of dengue virus increases disease severity in mice through complement activation.

Funder

National Medical Research Council

National Research Foundation-Prime Minister’s office, Republic of Singapore

Ministry of Education - Singapore

NMRC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference43 articles.