Chronic hypoxia–induced Cirbp hypermethylation attenuates hypothermic cardioprotection via down-regulation of ubiquinone biosynthesis-Reference-Cited by-同舟云学术

Chronic hypoxia–induced Cirbp hypermethylation attenuates hypothermic cardioprotection via down-regulation of ubiquinone biosynthesis

Published:2019-04-24 Issue:489 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Liu Yiwei¹^ORCID,Xing Junyue¹²^ORCID,Li Yongnan¹³,Luo Qipeng¹,Su Zhanhao¹^ORCID,Zhang Xiaoling¹²,Zhang Hao¹²⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

2. Heart Center of Henan Provincial People Hospital and Key Laboratory of Cardiac Regenerative Medicine, National Health Commission, Zhengzhou 451464, China.

3. Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730030, China.

4. Center for Pediatric Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

5. Heart Center and Shanghai Institute of Pediatric Congenital Heart Diseases, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.

Abstract

Chronic hypoxia–induced hypermethylation attenuates hypothermic cardioprotective effects of Cirbp and ubiquinone biosynthesis in rats and patients.

Funder

National Science Fund for Distinguished Young Scholars

CAMS Innovation Fund for Medical Sciences

Program for Professors in PUMC

Graduate Innovation Fund Project of Peking Union Medical College

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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