Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration

Author:

Tan Anna C. S.1234,Pilgrim Matthew G.56ORCID,Fearn Sarah7ORCID,Bertazzo Sergio8ORCID,Tsolaki Elena8,Morrell Alexander P.9,Li Miaoling10,Messinger Jeffrey D.10,Dolz-Marco Rosa12,Lei Jianqin11,Nittala Muneeswar G.11,Sadda Srinivas R.1112,Lengyel Imre513ORCID,Freund K. Bailey1214ORCID,Curcio Christine A.10

Affiliation:

1. Vitreous Retina Macula Consultants of New York, New York, NY 10022, USA.

2. LuEsther T. Mertz Retinal Research Center, Manhattan, Eye, Ear and Throat Hospital, New York, NY 10075, USA.

3. Singapore National Eye Center/Singapore Eye Research Institute Singapore, Singapore 168751, Singapore.

4. Duke-NUS Singapore, Singapore 168751, Singapore.

5. UCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.

6. Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London WC1X 8LD, UK.

7. Department of Materials, Imperial College London, London SW7 2AZ, UK.

8. Department of Medical Physics and Biomedical Engineering, University College London, Malet Place Engineering Building, London WC1E 6BT, UK.

9. Material Physics, Aston University, Aston Express Way, Birmingham B4 7ET, UK.

10. Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 32594-0019, USA.

11. Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA 90033, USA.

12. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

13. Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Belfast BT9 7BL, UK.

14. Department of Ophthalmology, New York University Langone School of Medicine, New York, NY 10016, USA.

Abstract

Hydroxyapatite nodules in retinal drusen may indicate risk for progression to advanced age-related macular degeneration.

Funder

Horizon 2020 Framework Programme

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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