Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer-Reference-Cited by-同舟云学术

Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer

Published:2019-02-13 Issue:479 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Singhal Sunil¹^ORCID,Stadanlick Jason¹^ORCID,Annunziata Michael J.¹,Rao Abhishek S.¹,Bhojnagarwala Pratik S.¹^ORCID,O’Brien Shaun²^ORCID,Moon Edmund K.²,Cantu Edward³,Danet-Desnoyers Gwenn⁴^ORCID,Ra Hyun-Jeong⁴,Litzky Leslie⁵,Akimova Tatiana⁵⁶^ORCID,Beier Ulf H.⁷^ORCID,Hancock Wayne W.⁵⁶^ORCID,Albelda Steven M.²,Eruslanov Evgeniy B.¹^ORCID

Affiliation:

1. Division of Thoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Division of Transplantation Immunology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

7. Division of Nephrology, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Abstract

PD-L1 + tumor cells, but not macrophages, are likely responsible for inhibiting tumor-specific T cells in early-stage human lung tumors.

Funder

U.S. Department of Defense

National Heart, Lung, and Blood Institute

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference43 articles.

1. Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

2. What does PD-L1 positive or negative mean?

3. Tumor associated macrophages and neutrophils in tumor progression

4. Origin and Functions of Tumor-Associated Myeloid Cells (TAMCs)

5. Myeloid-derived suppressor cells as regulators of the immune system

Cited by 180 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Functions of CAFs in microenvironment of non-small cell lung cancer: based on updated hallmarks of cancer;Oncologie;2024-09-02

2. Closed‐Loop Control of Macrophage Engineering Enabled by Focused‐Ultrasound Responsive Mechanoluminescence Nanoplatform for Precise Cancer Immunotherapy;Small;2024-08-05

3. Irradiated tumor cell-released microparticles enhance the therapeutic efficacy of PD-1 inhibitors by promoting M1-TAMs polarization in NSCLC brain metastases;Cancer Letters;2024-08

4. Research advances on signaling pathways regulating the polarization of tumor-associated macrophages in lung cancer microenvironment;Frontiers in Immunology;2024-07-31

5. Decoding the spatiotemporal heterogeneity of tumor-associated macrophages;Molecular Cancer;2024-07-27