Autologous tumor cell–derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion

Author:

Guo Mengfei1ORCID,Wu Feng1ORCID,Hu Guorong1ORCID,Chen Lian1ORCID,Xu Juanjuan1,Xu Pingwei2,Wang Xuan1,Li Yumei1,Liu Shuqing1ORCID,Zhang Shuai1ORCID,Huang Qi1ORCID,Fan Jinshuo1,Lv Zhilei1,Zhou Mei1ORCID,Duan Limin1,Liao Tingting1,Yang Guanghai3,Tang Ke2,Liu Bifeng4,Liao Xiaofei5,Tao Xiaonan1,Jin Yang1ORCID

Affiliation:

1. Key Laboratory of Pulmonary Diseases of Health Ministry, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

2. Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

3. Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

4. Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

5. School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

Abstract

This study investigated the application of a therapeutic tumor cell–derived microparticle-based nanodelivery platform in malignant pleural effusion.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hubei Province

Health and Planning Commission Fund of Hubei Province

Science and Technology Support Program of Hubei Province

Soundny (Sheng-Qi-An) Biotech

Wuhan Planning Project of Science and Technology

the Special Fund for Technological Innovation of Hubei

State Project for Essential Drug Research and Development

Special Fund for Industrail Transformation and Upgrading

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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