Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade-Reference-Cited by-同舟云学术

Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade

Published:2019-10-23 Issue:515 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Shekarian Tala¹²³⁴^ORCID,Sivado Eva²³⁵,Jallas Anne-Catherine²⁵,Depil Stéphane¹²³,Kielbassa Janice⁶,Janoueix-Lerosey Isabelle⁷⁸^ORCID,Hutter Gregor⁴^ORCID,Goutagny Nadège¹²,Bergeron Christophe²⁹,Viari Alain⁶¹⁰^ORCID,Valsesia-Wittmann Sandrine²⁵^ORCID,Caux Christophe¹²^ORCID,Marabelle Aurélien²⁹¹¹¹²^ORCID

Affiliation:

1. Centre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286 Université de Lyon, 69008 Lyon, France.

2. Centre de Lutte contre le Cancer Léon Bérard, 69008 Lyon, France.

3. Université Claude Bernard Lyon 1, 69100 Villeurbanne France.

4. University Hospital Basel, 4031 Basel, Switzerland.

5. INSERM UA8, 69008 Lyon, France.

6. Synergie Lyon Cancer, Plateforme de bioinformatique ‘Gilles Thomas’, Centre Léon Bérard, 69008 Lyon, France.

7. Institut Curie, PSL Research University, Inserm U830, 75005 Paris, France.

8. SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, 75005 Paris, France.

9. Institut d’Hématologie et d’Oncologie Pédiatrique, Centre Léon Bérard, 69008 Lyon, France.

10. Equipe Erable, INRIA Grenoble-Rhône-Alpes, 38330 Montbonnot-Saint Martin, France.

11. Gustave Roussy, Université Paris-Saclay, Drug Development Department (DITEP), 94805 Villejuif, France.

12. INSERM U1015, Gustave Roussy, 94805 Villejuif, France.

Abstract

Rotavirus vaccines have oncolytic properties and can overcome resistance to anti–PD-(L)1/CTLA-4 via RIG-I activation upon intratumoral administration.

Funder

Ligue Contre le Cancer

Institut National Du Cancer

Les 111 des Arts

Torocinelles

LABEX DEVweCAN

ALBEC

Institut d’Hématologie et d’Oncologie Pédiatrique

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine