Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome-Reference-Cited by-同舟云学术

Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome

Published:2019-05 Issue:490 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Habashi Jennifer Pardo¹^ORCID,MacFarlane Elena Gallo²^ORCID,Bagirzadeh Rustam²,Bowen Caitlin²^ORCID,Huso Nicholas²^ORCID,Chen Yichun²^ORCID,Bedja Djahida³,Creamer Tyler J.⁴^ORCID,Rykiel Graham²^ORCID,Manning Maurice⁵,Huso David³,Dietz Harry C.²⁶^ORCID

Affiliation:

1. Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA.

2. Center for Medical Genetics, Johns Hopkins University, Baltimore, MD 21287, USA.

3. Division of Comparative Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.

4. Department of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA.

5. Department of Cancer Biology, University of Toledo College of Medicine, Toledo, OH 43614, USA.

6. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

Protection from pregnancy-associated aortic dissection is achieved by decreasing oxytocin-induced ERK signaling in a mouse model of Marfan syndrome.

Funder

National Institutes of Health

Howard Hughes Medical Institute

Smilow Center for Marfan Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference34 articles.

1. Aortic Root Replacement in 372 Marfan Patients: Evolution of Operative Repair Over 30 Years

2. Cardiovascular Problems in Pregnant Women With Marfan Syndrome

3. Cardiovascular Problems in Pregnant Women with the Marfan Syndrome

4. Pregnancy and aortic root growth in the Marfan syndrome: a prospective study

5. Pregnancy in women with Marfan’s Syndrome

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