Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease

Author:

Rodrigues Filipe B.1ORCID,Byrne Lauren M.1ORCID,Tortelli Rosanna1ORCID,Johnson Eileanoir B.1ORCID,Wijeratne Peter A.2ORCID,Arridge Marzena34,De Vita Enrico345ORCID,Ghazaleh Naghmeh6ORCID,Houghton Richard6,Furby Hannah6,Alexander Daniel C.2ORCID,Tabrizi Sarah J.17ORCID,Schobel Scott8,Scahill Rachael I.1ORCID,Heslegrave Amanda79ORCID,Zetterberg Henrik791011,Wild Edward J.1ORCID

Affiliation:

1. UCL Huntington’s Disease Centre, UCL Queen Square Institute of Neurology, University College London, London WC1B 5EH, UK.

2. Centre for Medical Image Computing, Department of Computer Science, University College London, London WC1E 6BT, UK.

3. Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.

4. Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

5. Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

6. PD Personalised Healthcare, F. Hoffmann–La Roche Ltd., 4070 Basel, Switzerland.

7. UK Dementia Research Institute at UCL, London WC1E 6BT, UK.

8. Product Development Neuroscience, F. Hoffmann–La Roche Ltd., 4070 Basel, Switzerland.

9. Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.

10. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 431 80 Mölndal, Sweden.

11. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 431 80 Mölndal, Sweden.

Abstract

Longitudinal analysis in 80 patients shows that mutant huntingtin and neurofilament light could predict Huntington’s disease progression.

Funder

Huntington’s Disease Society of America

Hereditary Disease Foundation

CHDI Foundation

Wellcome

Horizon 2020 Framework Programme

Medical Research Council

Engineering and Physical Sciences Research Council

National Institute for Health Research

Alzheimer’s Society

European Research Council

Swedish Research Council Formas

Alzheimer’s Research UK

F. Hoffmann-La Roche Ltd

UK Dementia Research Institute

Swedish State

Innovative Medicines Initiative Joint Undertaking under EMIF grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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