Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup-Reference-Cited by-同舟云学术

Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup

Published:2021-05-26 Issue:595 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Touzart Aurore¹²^ORCID,Mayakonda Anand¹³^ORCID,Smith Charlotte²^ORCID,Hey Joschka¹³⁴^ORCID,Toth Reka¹^ORCID,Cieslak Agata²^ORCID,Andrieu Guillaume P.²^ORCID,Tran Quang Christine⁵⁶⁷⁸⁹^ORCID,Latiri Mehdi²,Ghysdael Jacques⁵⁶⁷⁸⁹,Spicuglia Salvatore¹⁰^ORCID,Dombret Hervé¹¹^ORCID,Ifrah Norbert¹²,Macintyre Elizabeth²^ORCID,Lutsik Pavlo¹¹³^ORCID,Boissel Nicolas¹¹,Plass Christoph¹¹³^ORCID,Asnafi Vahid²^ORCID

Affiliation:

1. Cancer Epigenomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

2. Université de Paris (Descartes), Institut Necker -Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, 75743 Paris, France.

3. Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany.

4. Germany-Israeli Helmholtz Research School in Cancer Biology, 69120 Heidelberg, Germany.

5. Institut Curie, Orsay, France.

6. CNRS UMR3348, Institut Curie, Orsay, France.

7. INSERM 1278, Centre Universitaire, Orsay, France.

8. PSL Research University, Paris, France.

9. Paris-Saclay, 91400 Orsay, France.

10. Aix-Marseille University, Inserm, Theories and Approaches of Genomic Complexity (TAGC), Equipe labellisée Ligue, UMR1090, 13288 Marseille, France.

11. Université Paris Diderot, Institut Universitaire d’Hématologie, EA-3518, Assistance Publique-Hôpitaux de Paris, University Hospital Saint-Louis, 75010 Paris, France.

12. PRES LUNAM, CHU Angers service des Maladies du Sang et INSERM U 892, 49933 Angers, France.

13. German Cancer Research Consortium (DKTK), 69120 Heidelberg, Germany.

Abstract

Characterization of adult T-ALL methylomes identifies a clinically aggressive hypermethylated subgroup sensitive to 5-azacytidine.

Funder

Helmholtz-Foundation

Le Programme Hospitalier de Recherche Clinique, Minist de lEmploi et de la SolidaritFrance and the Swiss Federal Government in Switzerland

French CARPEM (CAncer Research for PErsonalized Medicine) SIRIC program

DKFZ Postdoctoral fellowship

ARC-Labellisation and the associations Force hto and Laurette Fugain

Publisher

American Association for the Advancement of Science (AAAS)