Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth-Reference-Cited by-同舟云学术

Enhanced drug delivery to the reproductive tract using nanomedicine reveals therapeutic options for prevention of preterm birth

Published:2021-01-13 Issue:576 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zierden Hannah C.¹²^ORCID,Ortiz Jairo I.¹³,DeLong Kevin¹³,Yu Jingqi¹⁴^ORCID,Li Gaoshan¹²^ORCID,Dimitrion Peter¹,Bensouda Sabrine¹,Laney Victoria¹²,Bailey Anna¹⁴,Anders Nicole M.⁵,Scardina Morgan⁵,Mahendroo Mala⁶,Mesiano Sam⁷,Burd Irina⁸,Wagner Gunter⁹^ORCID,Hanes Justin¹²³⁴⁵^ORCID,Ensign Laura M.¹²³⁴⁵^ORCID

Affiliation:

1. Center for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

2. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

3. Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

4. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

5. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

6. Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

7. Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH 44106, USA.

8. Integrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, MD 21287, USA.

9. Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA.

Abstract

Vaginally delivered nanoformulations of progesterone and histone deacetylase inhibitors prevent inflammation-induced preterm birth in mice.

Funder

National Science Foundation

National Institutes of Health

National Cancer Institute

Burroughs Wellcome Fund

National Center for Advancing Translational Sciences

John Templeton Foundation

Hartwell Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference97 articles.

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5. 17-OHPC to prevent recurrent preterm birth in singleton gestations (PROLONG Study): A multicenter, international, randomized double-blind trial;Blackwell S. C.;Am. J. Perinatol.,2019

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