Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia-Reference-Cited by-同舟云学术

Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia

Published:2021-02-24 Issue:582 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zeisig Bernd B.¹²^ORCID,Fung Tsz Kan¹²^ORCID,Zarowiecki Magdalena¹^ORCID,Tsai Chiou Tsun¹,Luo Huacheng³^ORCID,Stanojevic Boban¹⁴^ORCID,Lynn Claire¹^ORCID,Leung Anskar Y. H.⁵^ORCID,Zuna Jan⁶,Zaliova Marketa⁶,Bornhauser Martin⁷,von Bonin Malte⁷,Lenhard Boris⁸⁹¹⁰^ORCID,Huang Suming³^ORCID,Mufti Ghulam J.¹²,So Chi Wai Eric¹²^ORCID

Affiliation:

1. Leukaemia and Stem Cell Biology Group, School of Cancer and Pharmaceutical Sciences, King’s College, London SE5 9NU, UK.

2. Department of Haematological Medicine, King’s College Hospital, London SE5 9RS, UK.

3. Division of Pediatric Hematology/Oncology, Department of Pediatrics, Penn State Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

4. Laboratory for Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Science, University of Belgrade, 11000 Belgrade, Serbia.

5. Department of Medicine, The University of Hong Kong, Pokfulam Road, HKSAR, China.

6. CLIP, Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague 5, Czech Republic.

7. Department of Medicine, University Hospital, 01307 Dresden, Germany.

8. Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK.

9. Computational Regulatory Genomics, MRC London Institute of Medical Sciences, London W12 0NN, UK.

10. Sars International Centre for Marine Molecular Biology, University of Bergen, N-5008 Bergen, Norway.

Abstract

Chemoresistant human CD34 −/lo /CD38 + MLL leukemic stem cells originate from HSCs and can be resensitized by targeting ABCC3 with fidaxomicin.

Funder

Cancer Research UK

Blood Cancer UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference68 articles.

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3. B. B. Zeisig C. W. So Cellular and molecular basis of KMT2A/MLL leukaemias: From transformation mechanisms to novel therapeutic strategies in Chromosomal Translocations and Genome Rearrangements in Cancer J. D. Rowley M. M. Le Beau T. H. Rabbitts Eds. (Springer 2016) chap. 11 pp. 223–250.

4. Tracing the cellular origin of cancer

5. Cells of origin in cancer

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