The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging-Reference-Cited by-同舟云学术

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging

Published:2021-12-08 Issue:623 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wohlwend Martin¹²³^ORCID,Laurila Pirkka-Pekka¹^ORCID,Williams Kristine⁴^ORCID,Romani Mario¹^ORCID,Lima Tanes¹^ORCID,Pattawaran Pattamaprapanont⁴^ORCID,Benegiamo Giorgia¹^ORCID,Salonen Minna⁵^ORCID,Schneider Bernard L.⁶^ORCID,Lahti Jari⁷⁸^ORCID,Eriksson Johan G.⁹¹⁰¹¹¹²^ORCID,Barrès Romain⁴^ORCID,Wisløff Ulrik²,Moreira José B. N.²^ORCID,Auwerx Johan¹^ORCID

Affiliation:

1. Laboratory of Integrative Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

2. Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), NO-7491 Trondheim, Norway.

3. Clinic of Cardiology, St. Olavs Hospital, Torgarden, NO-3250 Trondheim, Norway.

4. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.

5. Chronic Disease Prevention Unit, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.

6. Bertarelli Foundation Gene Therapy Platform, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1202 Geneva, Switzerland.

7. Turku Institute for Advanced Studies, University of Turku, FI-20014 Turku, Finland.

8. Department of Psychology and Logopedics, University of Helsinki, FI-00014 Helsinki, Finland.

9. Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, FI-00014 Helsinki, Finland.

10. Folkhälsan Research Center, University of Helsinki, FI-00014 Helsinki, Finland.

11. Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, SG-119228 Singapore, Singapore.

12. Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research, SG-117609 Singapore, Singapore.

Abstract

Exercise activates the lncRNA Cytor , which reestablishes fast-twitch muscle fibers in aged skeletal muscle, improving morphology and function.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference105 articles.

1. The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study

2. Sarcopenia and mortality among a population-based sample of community-dwelling older adults

3. Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength; a Quantitative Review

4. Muscle function in 164 men and women aged 20???84 yr

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