The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy-Reference-Cited by-同舟云学术

The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy

Published:2021-06-02 Issue:596 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rodríguez-Pascau Laura¹^ORCID,Vilalta Anna¹^ORCID,Cerrada Marc¹,Traver Estefania¹,Forss-Petter Sonja²,Weinhofer Isabelle²,Bauer Jan³^ORCID,Kemp Stephan⁴^ORCID,Pina Guillem¹,Pascual Sílvia¹,Meya Uwe¹^ORCID,Musolino Patricia L.⁵^ORCID,Berger Johannes²,Martinell Marc¹^ORCID,Pizcueta Pilar¹^ORCID

Affiliation:

1. Minoryx Therapeutics S.L., Barcelona 08302, Spain.

2. Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna 1090, Austria.

3. Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Vienna 1090, Austria.

4. Department of Clinical Chemistry and Pediatrics, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.

5. Neurosciences Intensive Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

Leriglitazone reduces pathologically activated microglia and protects neurons, astrocytes, and oligodendrocytes in experimental models of X-ALD.

Funder

Horizon 2020 Framework Programme

Generalitat de Catalunya

Politechnika Poznanska

CDTI

European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant

Nuclis

Enisa Jóvenes Emprendedores

Torres Quevedo

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference68 articles.

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4. The protein coded by the X-adrenoleukodystrophy gene is a peroxisomal integral membrane protein

5. The role of ELOVL1 in very long‐chain fatty acid homeostasis and X‐linked adrenoleukodystrophy

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