Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy

Author:

Sun Yi1ORCID,Chen Wei12,Torphy Robert J.1ORCID,Yao Sheng3ORCID,Zhu Gefeng3,Lin Ronggui1,Lugano Roberta4,Miller Emily N.1ORCID,Fujiwara Yuki1ORCID,Bian Li5,Zheng Linghua3ORCID,Anand Sudarshan6ORCID,Gao Fan7ORCID,Zhang Weizhou8ORCID,Ferrara Sarah E.9,Goodspeed Andrew E.910ORCID,Dimberg Anna4ORCID,Wang Xiao-Jing511ORCID,Edil Barish H.12ORCID,Barnett Carlton C.1ORCID,Schulick Richard D.1ORCID,Chen Lieping3ORCID,Zhu Yuwen1ORCID

Affiliation:

1. Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

2. Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang 310012, P. R. China.

3. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

4. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden.

5. Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

6. Department of Cell, Development and Cancer Biology, Oregon Health and Science University, Portland, OR 97239, USA.

7. Caltech Bioinformatics Resource Center at Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA.

8. Department of Pathology, University of Florida, Gainesville, FL 32610, USA.

9. University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA.

10. Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

11. Veterans Affairs Medical Center, VA Eastern Colorado Health Care System, Aurora, CO 80045, USA.

12. Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Abstract

Disruption of the molecular interaction between CD93 and IGFBP7 improves tumor vascular functions and thereby facilitates therapeutic interventions.

Funder

National Institutes of Health

American Cancer Society

National Cancer Institute

U.S. Department of Veterans Affairs

United Technologies

Wings of Hope for Pancreatic Research the Research Scholar

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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