Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice-Reference-Cited by-同舟云学术

Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice

Published:2021-06-30 Issue:600 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Fang Xiaoguang¹^ORCID,Huang Zhi¹,Zhai Kui¹,Huang Qian¹,Tao Weiwei¹,Kim Leo²³^ORCID,Wu Qiulian²⁴^ORCID,Almasan Alexandru¹⁵⁶,Yu Jennifer S.¹⁵⁶^ORCID,Li Xiaoxia⁷^ORCID,Stark George R.¹⁵^ORCID,Rich Jeremy N.²⁴^ORCID,Bao Shideng¹⁵⁸^ORCID

Affiliation:

1. Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

2. Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, San Diego, CA 92037, USA.

3. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

4. Division of Hematology Oncology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA.

5. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

6. Department of Radiation Oncology, Cleveland Clinic, OH 44195, USA.

7. Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

8. Center for Cancer Stem Cell Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Abstract

Targeting DNA-PK induces glioma stem cell differentiation by destabilizing SOX2 to inhibit tumor growth in mouse glioblastoma models.

Funder

National Institutes of Health

FUNDING

National Cancer Institute

National Institute of Neurological Disorders and Stroke

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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4. Sox proteins: regulators of cell fate specification and differentiation

5. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer

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