3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV

3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice

Published:2020-08-19 Issue:557 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rathnayake Athri D.¹^ORCID,Zheng Jian²^ORCID,Kim Yunjeong³^ORCID,Perera Krishani Dinali³^ORCID,Mackin Samantha²,Meyerholz David K.⁴^ORCID,Kashipathy Maithri M.⁵^ORCID,Battaile Kevin P.⁶^ORCID,Lovell Scott⁵^ORCID,Perlman Stanley²^ORCID,Groutas William C.¹^ORCID,Chang Kyeong-Ok³^ORCID

Affiliation:

1. Department of Chemistry, Wichita State University, Wichita, KS 67260, USA.

2. Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.

3. Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.

4. Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.

5. Protein Structure Laboratory, University of Kansas, Lawrence, KS 66045, USA.

6. NYX, New York Structural Biology Center, Upton, NY 11973, USA.

Abstract

Optimized small-molecule 3C-like protease inhibitors show potency against human coronaviruses in both cell culture and a mouse model.

Funder

National Institutes of Health

Publisher