Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3-Reference-Cited by-同舟云学术

Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3

Published:2021-04-28 Issue:591 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yuan Qianying¹²^ORCID,Basit Abdul¹²^ORCID,Liang Wenhua³^ORCID,Qu Rihao⁴⁵^ORCID,Luan Yi¹²^ORCID,Ren Chunguang¹²^ORCID,Li Ao¹²,Xu Xin³^ORCID,Liu Xiaoqing³^ORCID,Yang Chun³^ORCID,Kuo Andrew¹²^ORCID,Pierce Richard¹^ORCID,Zhang Longbo⁶^ORCID,Turk Benjamin²^ORCID,Hu Xin⁷^ORCID,Li Fangyong⁷^ORCID,Cui Weixue³^ORCID,Li Run³^ORCID,Huang Danxia³^ORCID,Mo Lili³^ORCID,Sessa William C.¹²^ORCID,Lee Patty J.⁸^ORCID,Kluger Yuval⁵^ORCID,Su Bing⁹^ORCID,Tang Wenwen¹²^ORCID,He Jianxing³^ORCID,Wu Dianqing¹²^ORCID

Affiliation:

1. Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA.

2. Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

3. Department of Thoracic Surgery/Oncology, First Affiliated Hospital of Guangzhou Medical University, China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou 510120, China.

4. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

5. Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.

6. Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.

7. Department of Biostatistics, Yale University School of Medicine, New Haven, CT 06520, USA.

8. Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

9. Shanghai Institute of Immunology, Shanghai Jiaotong University, Shanghai 200025, China.

Abstract

MAP3K inhibition attenuates acute lung injuries in mice and reduced edema in lung transplantation recipients.

Funder

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference75 articles.

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4. Impact of Randomized Trial Results on Acute Lung Injury Ventilator Therapy in Teaching Hospitals

5. The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

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