Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types-Reference-Cited by-同舟云学术

Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types

Published:2021-02-10 Issue:580 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Liu Qi¹^ORCID,Palomero Luis²^ORCID,Moore Jade¹^ORCID,Guix Ines¹,Espín Roderic²^ORCID,Aytés Alvaro²,Mao Jian-Hua³^ORCID,Paulovich Amanda G.⁴^ORCID,Whiteaker Jeffrey R.⁴^ORCID,Ivey Richard G.⁴^ORCID,Iliakis George⁵^ORCID,Luo Daxian⁵,Chalmers Anthony J.⁶^ORCID,Murnane John¹,Pujana Miquel Angel²^ORCID,Barcellos-Hoff Mary Helen¹^ORCID

Affiliation:

1. Department of Radiation Oncology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA.

2. ProCURE, Catalan Institute of Oncology, Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet del Llobregat, Barcelona 08908, Catalonia, Spain.

3. Biological Systems and Engineering Division, Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

4. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

5. Institute of Medical Radiation Biology, University of Duisburg-Essen, University Hospital Essen, Essen 45147, Germany.

6. Institute of Cancer Sciences and Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

Abstract

The impact of TGFβ signaling on DNA repair competency is observed in a pan-cancer analysis of survival after treatments that cause DNA damage.

Funder

National Cancer Institute

European Regional Development Fund

German Federal Ministry of Education and Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference83 articles.

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4. Misrepair in Context: TGFβ Regulation of DNA Repair

5. Repair Pathway Choices and Consequences at the Double-Strand Break

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